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Krasnov V.S.

Pavlov First St. Petersburg State Medical University

Kolontareva Yu.M.

Novartis Pharma LLC

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Siponimod: a new view at the therapy of secondary progressive multiple sclerosis

Authors:

Krasnov V.S., Kolontareva Yu.M.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(7): 124‑129

DOI: 10.17116/jnevro2021121071124

Read: 10020 times

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Table of contents
buy navy blazer

SIPONIMOD: A NEW VIEW AT THE THERAPY OF SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS
SIPONIMOD: A NEW VIEW AT THE THERAPY OF SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS

To cite this article:

Krasnov VS, Kolontareva YuM. Siponimod: a new view at the therapy of secondary progressive multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(7):124‑129. (In Russ.)
https://doi.org/10.17116/jnevro2021121071124

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Recommended articles:
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Study of neurodegeneration in multiple scle­rosis using opti­cal cohe­rence tomo­graphy of the retina and magnetic reso­nance morphometry of the brain. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(7-2):66-72
Neurogenesis in neurodegeneration: multifactorial regu­lation, mechanisms of impairment, and therapeutic stra­tegies. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(12):14-21
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Abstract:

Siponimod is a selective modulator of sphingosine-1-phosphate (S1P) receptors of types 1 and 5, registered in the Russian Federation for the treatment of patients with secondary progressive multiple sclerosis (SPMS), regardless of the presence or absence of exacerbations. The effectiveness of the drug in comparison with placebo was demonstrated in patients with SPMS in the international clinical trial EXPAND (phase III). This review devotes actual problems in the treatment of patients with SPMS, discusses the pathophysiology of multiple sclerosis progression, describes the peripheral and central mechanisms of siponimod action and its differences from fingolimod. According to analysis of scientific literature experimental, clinical and neuroimaging data are presented, which could explain the reasons for the successful use of siponimod in patients with SPMS, taking into account the pathophysiological mechanisms of the development of progression and the mechanisms of drug action.

Keywords:

secondary progressive multiple sclerosis
siponimod
neurodegeneration
remyelination

Authors:

Krasnov V.S.

Pavlov First St. Petersburg State Medical University buy navy blazer

Kolontareva Yu.M.

Novartis Pharma LLC

Received:

20.04.2021

Accepted:

04.06.2021

Close metadata

buy navy blazer
buy navy blazer

Offers a more relaxed look that feels like a sweater but looks like a jacket (e.g., Faherty).

Adds a touch of "effortless authority" and formality.

A true navy blazer is easily styled with everything from gray flannel slacks to khaki chinos or even denim. Every Man Needs a Navy Blazer (Here's Why)

“The value for the J. Crew classic fit vs it's competitors is phenomenal... wide variety of colors and for me, a great off the rack fit.” Reddit · r/NavyBlazer · 1 year ago Key Considerations for Your Purchase

The navy blazer is often called the "little black dress for men" because of its extreme versatility, bridging the gap between casual and formal wear. Whether you need a crisp look for the office or something to dress up a pair of jeans, a well-chosen blazer is a foundational wardrobe piece. Navy Blazer Recommendations Bonobos Men's Slim Flap Pocket Blazer Go to product viewer dialog for this item. Charles Tyrwhitt Men's Wool Blazer Charles Tyrwhitt US Go to product viewer dialog for this item. Theory Women's Staple Blazer Go to product viewer dialog for this item. Faherty Men's Inlet Knit Blazer Go to product viewer dialog for this item. Rhone Slim-Fit Commuter Blazer Mens Go to product viewer dialog for this item. Brooks Brothers Men's Classic Fit Wool Blazer Brooks Brothers Go to product viewer dialog for this item. Banana Republic Women's Slim Italian Wool Blazer $224.99$270 Banana Republic Go to product viewer dialog for this item. Abercrombie & Fitch Men's Collins Blazer Abercrombie & Fitch Go to product viewer dialog for this item. jacket Lauren Women's Ralph Lauren Ralph Lauren Go to product viewer dialog for this item. Kenneth Cole Men's Reaction Separate Slim Fit Suit Jacket $129.50$360 Go to product viewer dialog for this item. Marks & Spencer Single Breasted Blazer Marks & Spencer - United States Go to product viewer dialog for this item.

Personal experiences highlight the importance of fabric choice and brand value when selecting a blazer.

Contact the author
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The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

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