: The genetic variants must be strongly associated with the exposure of interest.
: Uses summary statistics from two separate groups (e.g., one group for LDL levels and another for heart disease data), which is often more cost-effective. Diseases - Mr Validity
For an MR report to be considered valid, it must demonstrate that the genetic instruments (SNPs) meet these criteria: : The genetic variants must be strongly associated
"Validity" in this context refers to the that a genetic instrument must satisfy to produce reliable, unbiased results. 🔬 Mendelian Randomization (MR) Report Diseases - Mr Validity
: There are no common causes (confounders) shared between the genetic variants and the outcome.