: Shiranui lures the bandits into the water, where one shark devours an entire boat of men. This highlights the episode's grim theme: the living being sacrificed to feed "the dead" (the sharks).

: Despite being their prisoner, Dororo saves the remaining bandits by diving into the sea to lure the shark toward a trap, allowing the men to kill one of the beasts.

Episode 16 is noted for its distinct "gloomy" aesthetic compared to previous episodes.

: While still a villain, Itachi shows a flicker of humanity and respect for Dororo’s spirit, even as he continues to exploit her for the map. ⚔️ Hyakkimaru's Side

: Itachi's crew attempts to cross to a cape where they believe Dororo’s father hid a massive treasure. They are intercepted by Shiranui , a one-armed man who controls two massive, mutated sharks (Jiromaru and Saburomaru).

The episode follows , who is currently separated from Hyakkimaru and held captive by Itachi and his band of ronin.