: The resulting stiffened tissue triggers non-canonical activation of the transcription factor GLI2 in epithelial cells.
Based on the full text of the study, supplemental videos (often named with similar codes) typically demonstrate:
: Injured epithelial cells release Sonic Hedgehog (SHH) ligands. g9048.mp4
: This signaling activates fibroblasts, which increase tissue stiffness by producing collagen.
: Observations of "leader cells" responding to GLI2 inhibition. : Observations of "leader cells" responding to GLI2
: Time-lapse footage of cancer cells moving across substrates of varying stiffness.
The research, published in journals such as and archived on PMC , explores how tissue stiffness and biochemical signaling work together to drive cancer growth. Key Research Findings g9048.mp4
: This "chemo-mechanical" loop promotes cell proliferation, migration, and the transition of normal cells into invasive cancer cells. Potential Video Content