The clinical presentation varies depending on the affected organ:
GVHD is a common complication following an . It occurs when the donor's immune cells (the "graft") recognize the recipient's body (the "host") as foreign and begin to attack it. Types of GVHD
Standard medical protocols focus on suppressing the donor's immune system to minimize damage to the host: Graft-Versus-Host Disease - StatPearls - NCBI Bookshelf
Often starts as a faint red, sunburn-like rash (frequently on the palms or soles) and can progress to severe blistering or peeling.
Chronic forms may cause joint stiffness, dry eyes, and fatigue, which can significantly hinder daily activities like driving or self-care. Management and Prevention
Disease progression is generally categorized into two main phases based on the timing and presentation of symptoms:
Typically develops within the first 100 days post-transplant. It primarily affects the skin, liver, and gastrointestinal (GI) tract.
Usually appears after 100 days and can affect nearly any organ system, including the eyes, lungs, and joints. Chronic GVHD can sometimes overlap with acute symptoms, known as overlap syndrome. Key Symptoms and Signs
