H12.rar -

: When an agonist (ligand) binds, H12 folds and "caps" the ligand-binding pocket. This creates a surface for coactivators to bind, triggering gene expression.

: The transition of H12 from a disordered state to a structured helix is essential for the precise regulation of RAR activity . Alternative Context: Construction H12.rar

: This is the C-terminal activation helix of the receptor. Its position acts as a "molecular switch". Transcriptional Regulation : : When an agonist (ligand) binds, H12 folds