He chooses to save Iris from the Mirrorverse but does so with computer-like logic that harms his friends and causes Iris to suffer a seizure.
Meredith continues to hide her pregnancy and subsequent miscarriage from Derek as she struggles to get cleared for surgery. She eventually breaks her silence when she realizes she can't handle his reckless driving anymore. [S7E2] Shock to the System
During a surgery, Cristina experiences a severe post-traumatic breakdown on the operating room floor. This leads her to question her place in the hospital and eventually give her wedding ring back to Owen. He chooses to save Iris from the Mirrorverse