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This molecular mechanism allows the ear to convert sound into neural signals at incredibly high speeds.

Sensing: The C2D domain is identified as critical, as disruptions in this area alter synaptic sound encoding. tm,cc,jp

ions are bound per domain, with specific significance for the . This molecular mechanism allows the ear to convert

Binding Sites: High-resolution structures revealed that multiple Ca 2+raised to the 2 plus power tm,cc,jp

Structure and function of otoferlin, a synaptic protein of ... - PMC

It tethers vesicles to the plasma membrane, facilitating sound encoding.

The protein utilizes several C2 domains (C2A-C2F) to bind Ca 2+raised to the 2 plus power and lipids, as shown in the protein structure below. 2. C2 Domains: Function & Interactions