Dnaddr.mica_p-1-10.1.var Now

: Some tumors have evolved to "shed" MICA from their surface. By releasing these proteins into the bloodstream, the cancer cells can "blind" the immune system’s NK cells, allowing the tumor to grow undetected [3, 8].

: Under normal conditions, MICA is rarely expressed on healthy cells. However, it becomes highly expressed when cells undergo viral infection, malignant transformation (cancer), or heat shock [2, 3]. Dnaddr.Mica_P-1-10.1.var

: MICA antibodies are a known factor in the rejection of kidney and heart transplants. Discrepancies between the donor's and recipient's MICA variants can trigger an immune response [6]. : Some tumors have evolved to "shed" MICA from their surface